About: SEQUENCE OF MURINE CORONAVIRUS JHM INDUCED NEUROPATHOLOGICAL CHANGES IN RATS

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SEQUENCE OF MURINE CORONAVIRUS JHM INDUCED NEUROPATHOLOGICAL CHANGES IN RATS
Creator	Wege, H Koga, M Ter, V
source	Medline; PMC
abstract	Infection of 21–25‐day‐old rats with the murine coronavirus JHM was followed either by an acute encephalomyelitis (AE) or subacute demyelinating encephalomyelitis (SDE). The major neuropathological finding in AE, which developed within 6–12 days pi. consisted of necrotizing lesions distributed mainly in the grey matter of the central nervous system (CNS). SDE developed 14–30 days pi. and affected rats revealed lesions of primary demyelination with predilection sites in the white matter. The time‐course for the development of lesions, virus replication and neutralizing antiviral antibody production within the first 3 weeks p.i. were studied. Within the first 2 weeks p.i., most rats showed no clinical signs but nevertheless revealed lesions typical of AE. In parallel to these neuropathological changes infectious virus could be isolated from brain and spinal cord. However, coinciding with multiplication of neutralizing JHM antibodies 10–12 days after infection no infectious virus was recoverable from CNS material. At this time many of the clinically healthy rats showed demyelinating lesions which were located at the typical predilection sites of SDE. These observations indicated that SDE was preceded by clinically silent AE lesions.
has issue date	2008-05-12(xsd:dateTime)
bibo:doi	10.1111/j.1365-2990.1984.tb00350.x
bibo:pmid	6330603
has license	no-cc
sha1sum (hex)	ffdd84a06e470242cef40cba59d9ab3218c420a4
schema:url	https://doi.org/10.1111/j.1365-2990.1984.tb00350.x
resource representing a document's title	SEQUENCE OF MURINE CORONAVIRUS JHM INDUCED NEUROPATHOLOGICAL CHANGES IN RATS
has PubMed Central identifier	PMC7168023
has PubMed identifier	6330603
schema:publication	Neuropathol Appl Neurobiol
resource representing a document's body	covid:ffdd84a06e470242cef40cba59d9ab3218c420a4#body_text
is schema:about of	named entity 'weeks' named entity 'developed' named entity 'studied' named entity 'rats' named entity 'neuropathological' »more»

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