About: Characterization of Sudan Ebolavirus infection in ferrets

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of Sudan Ebolavirus infection in ferrets
Creator	Qiu, Xiangguo Wong, Gary He, Shihua Embury-Hyatt, Carissa Kroeker, Andrea »more»
source	PMC
abstract	Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs. In our current study, we show that ferrets are susceptible to wild-type SUDV, providing a small animal model to directly study clinical isolates, screen experimental anti-SUDV compounds and potentially study viral transmission.
has issue date	2017-05-08(xsd:dateTime)
bibo:doi	10.18632/oncotarget.17694
bibo:pmid	28545034
has license	cc-by
sha1sum (hex)	ff78beee1e6b1052a3578f330c8f820c60411340
schema:url	https://doi.org/10.18632/oncotarget.17694
resource representing a document's title	Characterization of Sudan Ebolavirus infection in ferrets
has PubMed Central identifier	PMC5542265
has PubMed identifier	28545034
schema:publication	Oncotarget
resource representing a document's body	covid:ff78beee1e6b1052a3578f330c8f820c60411340#body_text
is schema:about of	named entity 'CHARACTERIZATION' named entity 'outbreaks' named entity 'asset' named entity 'lethal' named entity 'Therefore' »more»

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