About: Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient

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About: Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
Creator	Watanabe, Hiroshi Hamada, Nobuyuki Chijiwa, Katsumi Hara, Koyu Imamura, Yoshihiro »more»
source	PMC
abstract	The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs.
has issue date	2012-06-02(xsd:dateTime)
bibo:doi	10.1007/s10156-012-0429-0
bibo:pmid	22661221
has license	no-cc
sha1sum (hex)	fdc5139a2b08eb0238258dbee170f687506ac3b7
schema:url	https://doi.org/10.1007/s10156-012-0429-0
resource representing a document's title	Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
has PubMed Central identifier	PMC7101931
has PubMed identifier	22661221
schema:publication	J Infect Chemother
resource representing a document's body	covid:fdc5139a2b08eb0238258dbee170f687506ac3b7#body_text
is schema:about of	named entity 'received' named entity 'spanning trees' named entity 'virus' named entity 'virus' named entity 'nasopharynx' »more»

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