About: Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
Creator	Rappuoli, Rino De Gregorio, Ennio Finco, Oretta Bottomley, Matthew Oro, Ugo
source	PMC
abstract	Traditionally, vaccines have been developed by cultivating infectious agents and isolating the inactivated whole pathogen or some of its purified components. 20 years ago, reverse vaccinology enabled vaccine discovery and design based on information deriving from the sequence of microbial genomes rather than via the growth of pathogens. Today, the high throughput discovery of protective human antibodies, sequencing of the B cell repertoire, and the increasing structural characterization of protective antigens and epitopes provide the molecular and mechanistic understanding to drive the discovery of novel vaccines that were previously impossible. We are entering a “reverse vaccinology 2.0” era.
has issue date	2016-04-04(xsd:dateTime)
bibo:doi	10.1084/jem.20151960
bibo:pmid	27022144
has license	cc-by-nc-sa
sha1sum (hex)	fbcdafa6bac2c69c1f5afafc5338f777f234d592
schema:url	https://doi.org/10.1084/jem.20151960
resource representing a document's title	Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
has PubMed Central identifier	PMC4821650
has PubMed identifier	27022144
schema:publication	J Exp Med
resource representing a document's body	covid:fbcdafa6bac2c69c1f5afafc5338f777f234d592#body_text
is schema:about of	named entity 'PROTECTION' named entity 'ANTIGENS' named entity 'LICENSED' named entity 'STIMULATING' named entity 'NOVEL' »more»

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