About: Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus

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About: Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus
Creator	Jung, Kwonil Saif, Linda Gurnani, Ashita Renukaradhya, Gourapura
source	Elsevier; Medline; PMC
abstract	There is little information on the role of nitric oxide ((•)NO) in innate immunity to respiratory coronavirus (CoV) infections. We examined (•)NO levels by Greiss assay in bronchoalveolar lavage (BAL) of pigs infected with either porcine respiratory coronavirus (PRCV) or porcine reproductive and respiratory syndrome virus (PRRSV), a member of Nidovirales, like CoV. The antiviral effects of (•)NO on these two viruses were tested in an in vitro system using a (•)NO donor, S-nitroso-N-acetylpenicillamine (SNAP). We detected a large increase in (•)NO levels in BAL fluids of PRCV-infected pigs, but not in PRRSV-infected pigs. Pulmonary epithelial cell necrosis induced by PRCV coincided with increased (•)NO. Moreover, (•)NO levels in cell culture medium of PRRSV-infected alveolar macrophages (AMs) did not differ from that of mock-infected AMs. Antiviral assays showed that (•)NO significantly inhibited PRCV replication in swine testicular (ST) cells, whereas PRRSV was not susceptible to (•)NO based on the conditions tested. Our study suggests that unlike PRRSV which induces apoptosis in AMs, respiratory CoVs such as PRCV that infect pulmonary epithelial cells and cause cytolysis, induce (•)NO production in the respiratory tract. Thus, (•)NO may play a role in innate immunity to respiratory CoV infections by inhibiting viral replication.
has issue date	2010-08-01(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2010.03.022
bibo:pmid	20409593
has license	bronze-oa
sha1sum (hex)	fb9e429d9817c9f7a92c29465d146ecfeff29261
schema:url	https://doi.org/10.1016/j.vetimm.2010.03.022
resource representing a document's title	Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC2902704
has PubMed identifier	20409593
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:fb9e429d9817c9f7a92c29465d146ecfeff29261#body_text
is schema:about of	named entity 'ROLE' named entity 'INFORMATION' named entity 'COVS' named entity '80%' named entity 'S-NITROSO-N-ACETYLPENICILLAMINE' »more»

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