About: Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha

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About: Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha
Creator	Arai, Nobuaki Asai, Fumitoshi Inaba, Hiroaki Iwashita, Naoki Kato, Yukio »more»
source	PMC
abstract	Porphyromonas gulae is a major periodontal pathogen in dogs, which can be transmitted to their owners. A major virulence factor of P. gulae consists of a 41-kDa filamentous appendage (FimA) on the cell surface, which is classified into three genotypes: A, B, and C. Thus far, inhibition of periodontal disease in dogs remains difficult. The present study assessed the inhibitory effects of a combination of clindamycin and interferon alpha (IFN-α) formulation against P. gulae and periodontal disease. Growth of P. gulae was significantly inhibited by clindamycin; this inhibition had a greater effect on type C P. gulae than on type A and B isolates. In contrast, the IFN-α formulation inhibited the expression of IL-1β and COX-2 elicited by type A and B isolates, but not that elicited by type C isolates. Furthermore, periodontal recovery was promoted by the administration of both clindamycin and IFN-α formulation to dogs undergoing periodontal treatment; moreover, this combined treatment reduced the number of FimA genotypes in oral specimens from treated dogs. These results suggest that a combination of clindamycin and IFN-α formulation inhibit P. gulae virulence and thus may be effective for the prevention of periodontal disease induced by P. gulae.
has issue date	2020-02-20(xsd:dateTime)
bibo:doi	10.1038/s41598-020-59730-9
bibo:pmid	32080231
has license	cc-by
sha1sum (hex)	fad068abaa998641db5de8113fced6b3ef3d613f
schema:url	https://doi.org/10.1038/s41598-020-59730-9
resource representing a document's title	Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha
has PubMed Central identifier	PMC7033253
has PubMed identifier	32080231
schema:publication	Sci Rep
resource representing a document's body	covid:fad068abaa998641db5de8113fced6b3ef3d613f#body_text
is schema:about of	named entity 'virulence factor' named entity 'inhibited' named entity 'inhibited' named entity 'COX-2' named entity 'THEIR' »more»

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