About: Heme oxygenase-1 and carbon monoxide in pulmonary medicine

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Heme oxygenase-1 and carbon monoxide in pulmonary medicine
Creator	Choi, Augustine Ryter, Stefan Slebos, Dirk-Jan
source	PMC
abstract	Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammation, and apoptosis. By virtue of anti-inflammatory effects, HO-1 limits tissue damage in response to proinflammatory stimuli and prevents allograft rejection after transplantation. The transcriptional upregulation of HO-1 responds to many agents, such as hypoxia, bacterial lipopolysaccharide, and reactive oxygen/nitrogen species. HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXα, ferrous iron, and carbon monoxide (CO). The mechanisms by which HO-1 provides protection most likely involve its enzymatic reaction products. Remarkably, administration of CO at low concentrations can substitute for HO-1 with respect to anti-inflammatory and anti-apoptotic effects, suggesting a role for CO as a key mediator of HO-1 function. Chronic, low-level, exogenous exposure to CO from cigarette smoking contributes to the importance of CO in pulmonary medicine. The implications of the HO-1/CO system in pulmonary diseases will be discussed in this review, with an emphasis on inflammatory states.
has issue date	2003-08-07(xsd:dateTime)
bibo:doi	10.1186/1465-9921-4-7
bibo:pmid	12964953
has license	no-cc
sha1sum (hex)	faaf1022ccfe93b032c5608097a53543ba24aedb
schema:url	https://doi.org/10.1186/1465-9921-4-7
resource representing a document's title	Heme oxygenase-1 and carbon monoxide in pulmonary medicine
has PubMed Central identifier	PMC193681
has PubMed identifier	12964953
schema:publication	Respir Res
resource representing a document's body	covid:faaf1022ccfe93b032c5608097a53543ba24aedb#body_text
is schema:about of	named entity 'degradation' named entity 'HO-1' named entity 'pulmonary diseases' named entity 'HO-1' named entity 'expressed' »more»

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