About: Analyzing the impact of SARS CoV-2 on the human proteome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Analyzing the impact of SARS CoV-2 on the human proteome
Creator	Estrada, Ernesto
source	BioRxiv
abstract	The COVID-19 respiratory disease is caused by the novel coronavirus SARS-CoV-2, which uses the enzyme ACE2 to entry human cells. This disease is characterized by important damages at multi-organ level, partially due to the abundant expression of ACE2 in practically all human tissues. However, not every organ in which ACE2 is abundant is affected by SARS CoV-2, which suggests the existence of other multi-organ routes for transmitting the perturbations produced by the virus. We consider here diffusive processes through the protein-protein interaction (PPI) network of proteins targeted by SARS CoV-2 as such alternative route. We found a subdiffusive regime that allows the propagation of virus perturbations through the PPI network at a significant rate. By following the main subdiffusive routes across the PPI network we identify proteins mainly expressed in the heart, cerebral cortex, thymus, testis, lymph node, kidney, among others of the organs reported to be affected by COVID-19.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1101/2020.05.21.107912
has license	biorxiv
sha1sum (hex)	f407bf32c2171b16cb786897f2a35d4ee8a2464a
schema:url	https://doi.org/10.1101/2020.05.21.107912
resource representing a document's title	Analyzing the impact of SARS CoV-2 on the human proteome
schema:publication	bioRxiv
resource representing a document's body	covid:f407bf32c2171b16cb786897f2a35d4ee8a2464a#body_text
is schema:about of	named entity 'disease' named entity 'ALLOWS' named entity 'ALTERNATIVE' named entity 'PPI' named entity 'NOVEL CORONAVIRUS' »more»

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