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About:
A handheld point-of-care system for rapid detection of SARS-CoV-2 in under 20 minutes
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covidontheweb.inria.fr
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
A handheld point-of-care system for rapid detection of SARS-CoV-2 in under 20 minutes
Creator
Barclay, Wendy
Holmes, Alison
Bolt, Frances
Cavuto, Matthew
Davies, Frances
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source
MedRxiv
abstract
The COVID-19 pandemic is a global health emergency characterized by the high rate of transmission and ongoing increase of cases globally. Rapid point-of-care (PoC) diagnostics to detect the causative virus, SARS-CoV-2, are urgently needed to identify and isolate patients, contain its spread and guide clinical management. In this work, we report the development of a rapid PoC diagnostic test (< 20 min) based on reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and semiconductor technology for the detection of SARS-CoV-2 from extracted RNA samples. The developed LAMP assay was tested on a real-time benchtop instrument (RT-qLAMP) showing a lower limit of detection of 10 RNA copies per reaction. It was validated against 183 clinical samples including 127 positive samples (screened by the CDC RT-qPCR assay). Results showed 90.55% sensitivity and 100% specificity when compared to RT-qPCR and average positive detection times of 15.45 {+/-} 4.43 min. For validating the incorporation of the RT-LAMP assay onto our PoC platform (RT-eLAMP), a subset of samples was tested (n=40), showing average detection times of 12.89 {+/-} 2.59 min for positive samples (n=34), demonstrating a comparable performance to a benchtop commercial instrument. Paired with a smartphone for results visualization and geo-localization, this portable diagnostic platform with secure cloud connectivity will enable real-time case identification and epidemiological surveillance.
has issue date
2020-06-30
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bibo:doi
10.1101/2020.06.29.20142349
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medrxiv
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f3708f412b2c048be196e2da8ae03b26f476c5f5
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https://doi.org/10.1101/2020.06.29.20142349
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A handheld point-of-care system for rapid detection of SARS-CoV-2 in under 20 minutes
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covid:f3708f412b2c048be196e2da8ae03b26f476c5f5#body_text
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schema:about
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named entity 'detection'
named entity 'DETECTION'
named entity 'SARS-CoV-2'
named entity 'isothermal'
named entity 'RNA'
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