About: Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila

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About: Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila
Creator	Feng, Li Bates, Alexander Bock, Davi Correspondence, Scott Costa, Marta »more»
source	Medline; PMC
abstract	Different types of Drosophila dopaminergic neurons (DANs) reinforce memories of unique valence and provide state-dependent motivational control [1]. Prior studies suggest that the compartment architecture of the mushroom body (MB) is the relevant resolution for distinct DAN functions [2, 3]. Here we used a recent electron microscope volume of the fly brain [4] to reconstruct the fine anatomy of individual DANs within three MB compartments. We find the 20 DANs of the γ5 compartment, at least some of which provide reward teaching signals, can be clustered into 5 anatomical subtypes that innervate different regions within γ5. Reconstructing 821 upstream neurons reveals input selectivity, supporting the functional relevance of DAN sub-classification. Only one PAM-γ5 DAN subtype γ5(fb) receives direct recurrent feedback from γ5β′2a mushroom body output neurons (MBONs) and behavioral experiments distinguish a role for these DANs in memory revaluation from those reinforcing sugar memory. Other DAN subtypes receive major, and potentially reinforcing, inputs from putative gustatory interneurons or lateral horn neurons, which can also relay indirect feedback from MBONs. We similarly reconstructed the single aversively reinforcing PPL1-γ1pedc DAN. The γ1pedc DAN inputs mostly differ from those of γ5 DANs and they cluster onto distinct dendritic branches, presumably separating its established roles in aversive reinforcement and appetitive motivation [5, 6]. Tracing also identified neurons that provide broad input to γ5, β′2a, and γ1pedc DANs, suggesting that distributed DAN populations can be coordinately regulated. These connectomic and behavioral analyses therefore reveal further complexity of dopaminergic reinforcement circuits between and within MB compartments.
has issue date	2020-08-17(xsd:dateTime)
bibo:doi	10.1016/j.cub.2020.05.077
bibo:pmid	32619479
has license	cc-by
sha1sum (hex)	eff9df37b7bf9b42bfc4b6c896886b8be805f7ca
schema:url	https://doi.org/10.1016/j.cub.2020.05.077
resource representing a document's title	Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila
has PubMed Central identifier	PMC7443709
has PubMed identifier	32619479
schema:publication	Curr Biol
resource representing a document's body	covid:eff9df37b7bf9b42bfc4b6c896886b8be805f7ca#body_text
is schema:about of	named entity 'motivational' named entity 'types' named entity 'Drosophila' covid:arg/eff9df37b7bf9b42bfc4b6c896886b8be805f7ca named entity 'morphology' »more»

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