About: Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection

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About: Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection
Creator	Chang, Jianyu Jin, Yi Fan, Kai Hou, Lingyu Wan, Chunyan »more»
source	Medline; PMC
abstract	The development of novel broad-spectrum, antiviral agents against H5N1 infection is urgently needed. In this study, we evaluated the immunomodulatory activities and protective effect of Eupatorium adenophorum polysaccharide (EAP) against the highly pathogenic H5N1 subtype influenza virus. EAP treatment significantly increased the production of IL-6, TNF-α, and IFN-γ both in vivo and in vitro as measured by qPCR and ELISA. In a mouse infection model, intranasal administration of EAP at a dose of 25 mg/kg body weight prior to H5N1 viral challenge efficiently inhibited viral replication, decreased lung lesions, and increased survival rate. We further evaluated the innate immune recognition of EAP, as this process is regulated primarily Dectin-1 and mannose receptor (MR). These results indicate that EAP may have immunomodulatory properties and a potential prophylactic effect against H5N1 influenza infection. Our investigation suggests an alternative strategy for the development of novel antiinfluenza agents and benefits of E. adenophorum products.
has issue date	2013-09-18(xsd:dateTime)
bibo:doi	10.1155/2013/194976
bibo:pmid	24159339
has license	cc-by
sha1sum (hex)	efba2008a6ccf1ad2614aebd79a6a741ea6538b9
schema:url	https://doi.org/10.1155/2013/194976
resource representing a document's title	Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection
has PubMed Central identifier	PMC3789439
has PubMed identifier	24159339
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:efba2008a6ccf1ad2614aebd79a6a741ea6538b9#body_text
is schema:about of	named entity 'EAP' named entity 'viral replication' named entity 'dose' named entity 'HIGHLY' named entity 'IFN' »more»

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