About: Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection

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About: Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection
Creator	Wong, M Alving, K Broliden, K Janson, C Levinson, P »more»
source	Elsevier; Medline; PMC
abstract	Abstract Background Viral respiratory infections have been associated with up to 80% of wheezing episodes and asthma exacerbations. However, studies on the role of these viruses in asthmatic patients in the interval between exacerbations are sparse. This study aimed to determine the presence of respiratory viruses, without symptoms of infection, in the airways of young asthmatics as compared to healthy controls. Material and Methods Patients 10–35 years of age with stable asthma and a group of healthy controls were analyzed regarding the presence of RNA from common respiratory viruses in nasopharyngeal aspirates by PCR. Self-reported asthma control and quality of life, fraction of exhaled nitric oxide (FeNO), spirometry, and bronchial responsiveness to methacholine were recorded. Blood samples were collected to assess IgE sensitisation and eosinophil cationic protein (ECP) levels. Results In 354 patients with asthma and 108 healthy controls, human rhinovirus (HRV) was the only virus detected (4.5% of asthmatics vs. 0.9% of controls; p = 0.08). HRV+ asthma patients had a higher degree of aeroallergen IgE sensitisation (median 37.7 vs. 10.4 kUA/L, p = 0.04), and a tendency for higher levels of serum ECP (median 17.2 vs. 12.6 μg/L, p = 0.07), as compared to their HRV− counterparts. Conclusions Absence of symptoms of respiratory tract infection notwithstanding, HRV seems to be more prevalent in the airways of adolescents and young adults with asthma and a high degree of aeroallergen IgE sensitisation than in controls. The presence of HRV seems also to be related to systemic eosinophilic inflammation despite ongoing treatment with inhaled corticosteroids.
has issue date	2016-06-30(xsd:dateTime)
bibo:doi	10.1016/j.rmed.2016.04.002
bibo:pmid	27215496
has license	els-covid
sha1sum (hex)	ef3c9390b2dac4ab54e3bd766b7bb28d03511802
schema:url	https://doi.org/10.1016/j.rmed.2016.04.002
resource representing a document's title	Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection
has PubMed Central identifier	PMC7125923
has PubMed identifier	27215496
schema:publication	Respiratory Medicine
resource representing a document's body	covid:ef3c9390b2dac4ab54e3bd766b7bb28d03511802#body_text
is schema:about of	named entity 'This' named entity 'levels' named entity 'serum' named entity 'life' named entity 'patients' »more»

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