About: Interleukin-6 blockade for severe COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interleukin-6 blockade for severe COVID-19
Creator	Paule, Romain Roumier, Mathilde Ackermann, Félix Groh, Matthieu Vallée, Alexandre
source	MedRxiv
abstract	In the context of COVID-19 pandemic and growing tensions worldwide regarding healthcare facilities, there is an urgent need for effective treatments likely to reduce the crunch of ICU beds. Following the assumption by Mehta and colleagues who exhorted physicians to screen patients with severe COVID-19 for hyperinflammation and investigate immunomodulatory drugs in this setting, we relate our short-term - yet promising - experience regarding IL6 blockade with tocilizumab in 30 selected patients of less than 80 years of age, >5 days of prior disease duration, severe (i.e. requiring strictly over 6L/min of oxygen therapy) rapidly deteriorating (i.e. increase by more than 3L/min of oxygen flow within the previous 12 hours) COVID-19-related pneumonia. By comparison with a control group of patients (matched for age, gender and disease severity using the inverse probability of treatment weighted methodology) that did not receive tocilizumab. We demonstrate that, in highly selected patients, IL6 blockade could curb the %22cytokine storm%22, prevent ICU admission and the requirement for mechanical ventilation. Notwithstanding the shortcomings of this retrospective small sample-size study, we believe that these preliminary findings support the fostering of research efforts in the fight against COVID-19-induced inflammation, especially before patients require admission to the ICU.
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.1101/2020.04.20.20061861
has license	medrxiv
sha1sum (hex)	eec1b65d2870e77c6b20afb7872f3a5fb16e28c1
schema:url	https://doi.org/10.1101/2020.04.20.20061861
resource representing a document's title	Interleukin-6 blockade for severe COVID-19
resource representing a document's body	covid:eec1b65d2870e77c6b20afb7872f3a5fb16e28c1#body_text
is schema:about of	named entity 'growing' named entity 'patients' named entity 'rapidly' named entity 'INCREASE' named entity 'FOLLOWING' »more»

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