About: Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures

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About: Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures
Creator	Hirayama, Mikio Suzumura, A Lavi, E Dambach, D Dambach, Donna »more»
source	Elsevier; Medline; PMC
abstract	Abstract MHV-A59 causes a chronic demyelinating disease in mice which is accompanied by persistence of viral genome in white matter. As part of the investigation into the mechanism of viral persistence, infection of glial cells, probable targets for chronic infection, was studied by the use of mixed glial, enriched oligodendrocyte and enriched astrocyte cultures. Following MHV-A59 infection in vitro, approximately 10% of oligodendrocytes and 30% of astrocytes expressed viral antigens in the absence of overt cytopathic effect. All cultures released infectious virus for the lifetime of the cultures, for at least 45 days in the case of mixed glial cultures. Cultures derived from previously infected mice were similar to those infected in vitro with respect to percentage of cells expressing viral antigen and levels of infectious virus produced. These results show (1) that glial cells are early sites of infection in vivo as well as sites of infection in in vitro cultures, and (2) that glial cells support a non-lytic but productive infection in vitro and thus may contribute to viral persistence in vivo.
has issue date	1987-08-31(xsd:dateTime)
bibo:doi	10.1016/0882-4010(87)90066-0
bibo:pmid	2849019
has license	els-covid
sha1sum (hex)	ee9217a3e0a28ab75f1099e944372772f807cc83
schema:url	https://doi.org/10.1016/0882-4010%2887%2990066-0
resource representing a document's title	Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures
has PubMed Central identifier	PMC7135766
has PubMed identifier	2849019
schema:publication	Microbial Pathogenesis
resource representing a document's body	covid:ee9217a3e0a28ab75f1099e944372772f807cc83#body_text
is schema:about of	named entity 'CELL CULTURES' named entity 'A59' named entity 'GLIAL CELL' named entity 'MOUSE HEPATITIS VIRUS' named entity 'INFECTION' »more»

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