About: Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome
Creator	Cardiovascular, Pulmonary Renal Pathology The,
source	Elsevier; Medline; PMC
abstract	Dipeptidyl peptidase 4 (DPP4, CD26), a type II transmembrane ectopeptidase, is the receptor for the Middle Eastern respiratory syndrome coronavirus (MERS-CoV). MERS emerged in 2012 and has a high mortality associated with severe lung disease. A lack of autopsy studies from MERS fatalities has hindered understanding of MERS-CoV pathogenesis. We investigated the spatial and cellular localization of DPP4 to evaluate an association MERS clinical disease. DPP4 was rarely detected in the surface epithelium from nasal cavity to conducting airways with a slightly increased incidence in distal airways. DPP4 was also found in a subset of mononuclear leukocytes and in serous cells of submucosal glands. In the parenchyma, DPP4 was found principally in type I and II cells and alveolar macrophages and was also detected in vascular endothelium (eg, lymphatics) and pleural mesothelia. Patients with chronic lung disease, such as chronic obstructive pulmonary disease and cystic fibrosis, exhibited increased DPP4 immunostaining in alveolar epithelia (type I and II cells) and alveolar macrophages with similar trends in reactive mesothelia. This finding suggests that preexisting pulmonary disease could increase MERS-CoV receptor abundance and predispose individuals to MERS morbidity and mortality, which is consistent with current clinical observations. We speculate that the preferential spatial localization of DPP4 in alveolar regions may explain why MERS is characterized by lower respiratory tract disease.
has issue date	2016-01-01(xsd:dateTime)
bibo:doi	10.1016/j.ajpath.2015.09.014
bibo:pmid	26597880
has license	hybrid-oa
sha1sum (hex)	ee85fc403280eda861fa1dc3b2446155219476f2
schema:url	https://doi.org/10.1016/j.ajpath.2015.09.014
resource representing a document's title	Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome
has PubMed Central identifier	PMC4715219
has PubMed identifier	26597880
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:ee85fc403280eda861fa1dc3b2446155219476f2#body_text
is schema:about of	named entity 'Peptidase' named entity 'DIPEPTIDYL PEPTIDASE 4' named entity 'RESPIRATORY TRACT' named entity 'DISTRIBUTION' named entity 'MIDDLE EAST RESPIRATORY SYNDROME' »more»

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