About: Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes

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About: Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes
Creator	Zhou, Junwei Kwok-Wing, Stephen Tsui, Au, Ka-Wing Kou, Ying-Chuck »more»
source	Medline; PMC
abstract	Cardiovascular diseases have been one of the leading killers among the human population worldwide. During the heart development, cardiomyocytes undergo a transition from hyperplastic to hypertrophic growth with an unclear underlying mechanism. In this study, we aim to investigate how interferons differentially stimulate the interferon‐inducible transmembrane (IFITM) family proteins and further be involved in the process of heart development. The expression levels of three IFITM family members, IFITM1, IFITM2, and IFITM3 were investigated during Sprague–Dawley rat myocardial development and differentiation of H9C2 cardiomyocytes. The effects of interferon‐α, ‐β, and ‐γ on DNA synthesis in H9C2 cells were also characterized. Up‐regulation of IFITM1 and IFITM3 were observed during the heart development of Sprague–Dawley rat and the differentiation of H9C2 cells. Moreover, interferon‐α and ‐β induce the expression of IFITM3 while interferon‐γ up‐regulates IFITM1. Finally, interferon‐α and ‐β were demonstrated to inhibit DNA synthesis during H9C2 cell differentiation. Our results indicated interferons are potentially involved in the differentiation and cell proliferation during heart development. J. Cell. Biochem. 113: 841–847, 2012. © 2011 Wiley Periodicals, Inc.
has issue date	2012-01-20(xsd:dateTime)
bibo:doi	10.1002/jcb.23412
bibo:pmid	22021094
has license	no-cc
sha1sum (hex)	ee410e6bc6af0cb21342112a5ab4a429f41bc219
schema:url	https://doi.org/10.1002/jcb.23412
resource representing a document's title	Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes
has PubMed Central identifier	PMC7166870
has PubMed identifier	22021094
schema:publication	J Cell Biochem
resource representing a document's body	covid:ee410e6bc6af0cb21342112a5ab4a429f41bc219#body_text
is schema:about of	named entity 'investigated' named entity 'hyperplastic' named entity 'differentiation' named entity 'Proliferation' named entity 'MECHANISM' »more»

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