About: Thyroid function abnormalities in COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Thyroid function abnormalities in COVID-19 patients
Creator	Zhao, Hong Xu, Xiaowei Xu, Kaijin Ni, Qin Qiu, Yunqing »more»
source	MedRxiv
abstract	Background: The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects human thyroid function remains unknown. Methods: 84 hospitalized COVID-19 patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were respectively enrolled in this study. In addition, 73 other patients with pneumonia and 819 healthy subjects were included as controls. Results: We found that the levels of TT3 and TSH were lower in COVID-19 patients than control groups (p<0.001). Within the group of COVID-19 patients, 61.9% patients (52/84) presented with thyroid function abnormalities. We found a larger proportion of patients in severe condition exhibited thyroid dysfunction than mild/moderate cases (90.4% vs. 50.0%, p < 0.001). Patients with thyroid dysfunction tended to have increased interval time for negative conversion of viral nucleic acid (14.1 {+/-} 9.4 vs. 10.6 {+/-} 8.3 days, p = 0.088). To note, thyroid dysfunction was also associated with decreased lymphocytes (p < 0.001) and increased CRP (p = 0.002). In 7 patients with dynamic changes of thyroid function, we observed the levels of TT3 and TSH gradually increased and reached normal range without thyroid hormone replacement at Day 30 post-admission. The correlation between TT3 and TSH level seemed to be positive rather than negative in the early stage, and gradually turned to be negatively related over time. Conclusions: Thyroid function abnormalities are common in COVID-19 patients, especially in severe cases. This might be caused by virus attack and damage to the thyroid-pituitary axis. Therefore, more attention should be paid to thyroid function during treatment of COVID-19, and close follow-up is also needed after discharge.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1101/2020.06.15.20130807
has license	medrxiv
sha1sum (hex)	edb8cebd86d0ad4e7ecf8e61a0aa4fb805b29500
schema:url	https://doi.org/10.1101/2020.06.15.20130807
resource representing a document's title	Thyroid function abnormalities in COVID-19 patients
resource representing a document's body	covid:edb8cebd86d0ad4e7ecf8e61a0aa4fb805b29500#body_text
is schema:about of	named entity 'patients' named entity 'Day' named entity 'close' named entity 'China' named entity 'conversion' »more»

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