About: Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19

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About: Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19
Creator	Kasianov, Artem Sheval, Eugene Valyaeva, Anna Vassetzky, Yegor Zharikova, Anastasia
source	BioRxiv
abstract	SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be infected by SARS-CoV-2, which can lead to defects in regeneration capacity and account for the severity of SARS-CoV-2 infection and its consequences.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1101/2020.05.23.107334
has license	biorxiv
sha1sum (hex)	ed7b8cc1ec3456d6e2db62b152271636ffab60af
schema:url	https://doi.org/10.1101/2020.05.23.107334
resource representing a document's title	Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19
schema:publication	bioRxiv
resource representing a document's body	covid:ed7b8cc1ec3456d6e2db62b152271636ffab60af#body_text
is schema:about of	named entity 'lead' named entity 'respiratory tract' named entity 'lung' named entity 'express' named entity 'severe' »more»

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