About: Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody

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About: Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody
Creator	Bakar, Abu Cheong, Wei Leow, Chiuan Leow, Yee Majeed, Abdul
source	Elsevier; Medline; PMC
abstract	Abstract Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance of mAbs in certain applications. To address this problem, the exploration of new antigen binders is extensively required in relation to improve the quality of current diagnostic platforms. In recent years, a new immunoglobulin-based protein, namely variable domain of new antigen receptor (VNAR) was discovered in sharks. Unlike conventional mAbs, several advantages of VNARs, include small size, better thermostability and peculiar paratope structure have attracted interest of researchers to further explore on it. This article aims to first present an overview of the shark VNARs and outline the characteristics as an outstanding new reagent for diagnostic and therapeutic applications.
has issue date	2020-03-15(xsd:dateTime)
bibo:doi	10.1016/j.ijbiomac.2020.01.039
bibo:pmid	31926922
has license	els-covid
sha1sum (hex)	ec48ae032c1cfe0d222d36e4e640efa5b21e78bd
schema:url	https://doi.org/10.1016/j.ijbiomac.2020.01.039
resource representing a document's title	Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody
has PubMed Central identifier	PMC7112388
has PubMed identifier	31926922
schema:publication	International Journal of Biological Macromolecules
resource representing a document's body	covid:ec48ae032c1cfe0d222d36e4e640efa5b21e78bd#body_text
is schema:about of	named entity 'THERAPEUTIC' named entity 'exploration' named entity 'explore' named entity 'current' named entity 'ambient temperature' »more»

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