About: Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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About: Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses
Creator	Inozume, Takashi Ito, Mamoru Ito, Ryoji Iwata, Takashi Ka, Yuyo »more»
source	Medline; PMC
abstract	Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg (null)) mice, severe graft versus host disease (GVHD) hinders long term detailed analysis. Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells with little sign of GVHD. Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab, indicating induction of antigen-specific B cells in the NOG-dKO mice. Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells, indicating the induction of antigen-specific T cells in the NOG-dKO mice. Adoptive cell therapies (ACTs) using melanoma antigen recognized by T cells (MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells. ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice, in which changes in human cancer phenotypes by immune intervention, such as increased CD271 expression, could be evaluated. Therefore, NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.
has issue date	2017-11-20(xsd:dateTime)
bibo:doi	10.1038/cmi.2017.106
bibo:pmid	29151581
has license	bronze-oa
sha1sum (hex)	ec119e55e550fa9ecd1b3fdd91a21e6f88732880
schema:url	https://doi.org/10.1038/cmi.2017.106
resource representing a document's title	Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses
has PubMed Central identifier	PMC6207709
has PubMed identifier	29151581
schema:publication	Cellular & Molecular Immunology
resource representing a document's body	covid:ec119e55e550fa9ecd1b3fdd91a21e6f88732880#body_text
is schema:about of	named entity 'effector' named entity 'mice' named entity 'human' named entity 'specific' named entity 'Therefore' »more»

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