About: Transmission dynamics and risk factors for pandemic H1N1‐related illness: outbreak investigation in a rural community of British Columbia, Canada

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About: Transmission dynamics and risk factors for pandemic H1N1‐related illness: outbreak investigation in a rural community of British Columbia, Canada Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transmission dynamics and risk factors for pandemic H1N1‐related illness: outbreak investigation in a rural community of British Columbia, Canada
Creator	Authority, Prince Bc, Canada C Northern Health, George,
source	Medline; PMC
abstract	Please cite this paper as: Janjua et al. (2012) Transmission dynamics and risk factors for pandemic H1N1‐related illness: outbreak investigation in a rural community of British Columbia, Canada. Influenza and Other Respiratory Viruses 6(3), e54–e62. Objective To characterize the first‐wave epidemiologic features of influenza‐like illness (ILI) associated with the novel pandemic A/H1N1 [A(H1N1)pdm09] virus. Methods We used generalized linear mixed models (GLMM) to assess risk factors and non‐parametric and/or parametric distributions to estimate attack rates, secondary attack rates (SAR), duration of illness, and serial interval during a laboratory‐confirmed community outbreak of A(H1N1)pdm09 clustered around on‐reserve residents and households of an elementary school in rural British Columbia, Canada, in late April/early May 2009. ILI details were collected as part of outbreak investigation by community telephone survey in early June 2009. Results Overall, 92/408 (23%) of participants developed ILI and 36/408 (9%) experienced medically attended ILI (MAILI). The overall SAR in households was 22%: highest among participants 1–4 years of age (yoa) (50%) followed by <1 yoa (38%), 5–8 yoa (20%), 10–19 yoa (13%), 20–49 yoa (20%), and 50–64 yoa (0%). The median serial interval was estimated at 3·5 days (95% CI: 2·1–5·1). In multivariable GLMM analysis, having a chronic condition (OR: 2·58; 95% CI: 1·1–6·04), younger age [1–8 yoa: OR: 4·63; 95% CI: 2·25–9·52; 9–19 yoa: OR: 1·95; 95% CI: 0·97–3·9 (referent: ≥20 yoa)] and receipt of 2008–2009 influenza vaccine (OR: 2·68; 95% CI: 1·37–5·25) were associated with increased risk of ILI. Median duration of illness was 9 days, longer among those with chronic conditions (21 days). Median time to seeking care after developing illness was 4·5 days. On‐reserve participants had higher chronic conditions, household density, ILI, MAILI, and SAR. Conclusions During a community outbreak of A(H1N1)pdm09‐related illness, we identified substantial clinical ILI attack rates exceeding 20% with secondary household attack rates as high as 50% in young children. The serial interval was short suggesting a narrow period to prevent transmission.
has issue date	2012-03-02(xsd:dateTime)
bibo:doi	10.1111/j.1750-2659.2012.00344.x
bibo:pmid	22385647
has license	no-cc
sha1sum (hex)	eb682a5cbe2942e78f0ec4959adce8475d5723d5
schema:url	https://doi.org/10.1111/j.1750-2659.2012.00344.x
resource representing a document's title	Transmission dynamics and risk factors for pandemic H1N1‐related illness: outbreak investigation in a rural community of British Columbia, Canada
has PubMed Central identifier	PMC4986582
has PubMed identifier	22385647
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:eb682a5cbe2942e78f0ec4959adce8475d5723d5#body_text
is schema:about of	named entity '2009' named entity 'ATTACK RATES' named entity 'INFLUENZA-LIKE ILLNESS' named entity 'BRITISH COLUMBIA' named entity 'EARLY' »more»

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