About: Chapter Four Coronavirus cis-Acting RNA Elements

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Chapter Four Coronavirus cis-Acting RNA Elements
Creator	Ziebuhr, J Fricke, M Madhugiri, R Marz, M
source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins. The protein complex is thought to bind specific cis-acting RNA elements primarily located in the 5′- and 3′-terminal genome regions and upstream of the open reading frames located in the 3′-proximal one-third of the genome. Here, we review our current understanding of coronavirus cis-acting RNA elements, focusing on elements required for genome replication and packaging. Recent bioinformatic, biochemical, and genetic studies suggest a previously unknown level of conservation of cis-acting RNA structures among different coronavirus genera and, in some cases, even beyond genus boundaries. Also, there is increasing evidence to suggest that individual cis-acting elements may be part of higher-order RNA structures involving long-range and dynamic RNA–RNA interactions between RNA structural elements separated by thousands of nucleotides in the viral genome. We discuss the structural and functional features of these cis-acting RNA elements and their specific functions in coronavirus RNA synthesis.
has issue date	2016-12-31(xsd:dateTime)
bibo:doi	10.1016/bs.aivir.2016.08.007
bibo:pmid	27712622
has license	els-covid
sha1sum (hex)	ea5e25ea4e0e08805b724ee4ae848b71e0e4704b
schema:url	https://doi.org/10.1016/bs.aivir.2016.08.007
resource representing a document's title	Chapter Four Coronavirus cis-Acting RNA Elements
has PubMed Central identifier	PMC7112319
has PubMed identifier	27712622
schema:publication	Advances in Virus Research
resource representing a document's body	covid:ea5e25ea4e0e08805b724ee4ae848b71e0e4704b#body_text
is schema:about of	named entity 'RNA' named entity 'RNA' named entity 'ELEMENTS' named entity 'CORONAVIRUS' named entity 'CIS' »more»

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