About: The immune response to a recombinant Lactococcus lactis oral vaccine against foot-and-mouth disease virus in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The immune response to a recombinant Lactococcus lactis oral vaccine against foot-and-mouth disease virus in mice
Creator	Liu, Xinsheng Li, Pan Jianliang, Lv Linlin, Qi Peng, Zhou »more»
source	Medline; PMC
abstract	OBJECTIVE: Development of an effective mucosal vaccine to induce specific immune responses against Foot-and-mouth disease virus (FMDV). RESULTS: For this purpose, the FMDV VP1 gene (SPVP1) was optimized and synthesized based on the codon bias of Lactococcus lactis (L. lactis), and then incorporated in the plasmid pNZ8148. L. lactis NZ9000 containing the pNZ8148-SPVP1 recombinant plasmid was used as an oral delivery vehicle to induce anti-FMDV mucosal and systemic immune responses in mice. After confirmation that the SPVP1 protein was expressed successfully in the recombinant L. latic, the mice were orally challenged with NZ9000-pNZ8148, NZ9000-pNZ8148-SPVP1, phosphate-buffered saline as a mock infection group, or with inactivated vaccine as a positive group. Mice immunized with NZ9000-pNZ8148-SPVP1 produced high levels of mucosal secretory IgA (sIgA), antigen-specific serum IgG, IgA, and neutralizing antibodies, and developed stronger cell-mediated immune reactions and significant T spleen lymphocyte proliferation. Furthermore, the recombinant group generated much higher levels of IFN-γ, IL-2, IL-4, IL-5, and IL-10 than the other groups. CONCLUSIONS: Potent immune responses were successfully elicited in mice with FMDV VP1 delivered through L. lactis.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.1007/s10529-020-02900-6
bibo:pmid	32385744
has license	no-cc
sha1sum (hex)	e6db53d28aac70aae85d0b3d155266e3d14a1069
schema:url	https://doi.org/10.1007/s10529-020-02900-6
resource representing a document's title	The immune response to a recombinant Lactococcus lactis oral vaccine against foot-and-mouth disease virus in mice
has PubMed Central identifier	PMC7210100
has PubMed identifier	32385744
schema:publication	Biotechnol Lett
resource representing a document's body	covid:e6db53d28aac70aae85d0b3d155266e3d14a1069#body_text
is schema:about of	named entity 'positive' named entity 'group' named entity 'developed' named entity 'cell-mediated' named entity 'mucosal' »more»

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