About: Distinct systems serology features in children, elderly and COVID patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distinct systems serology features in children, elderly and COVID patients
Creator	Krammer, Florian Watterson, Daniel Hensen, Luca Kedzierska, Katherine Juno, Jennifer »more»
source	MedRxiv
abstract	SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and economic disruptions. COVID-19 results in higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive coronavirus immunological responses, induced by circulating human coronaviruses, is critical to understand such divergent clinical outcomes. The cross-reactivity of coronavirus antibody responses of healthy children (n=89), adults (n=98), elderly (n=57), and COVID-19 patients (n=19) were analysed by systems serology. While moderate levels of cross-reactive SARS-CoV-2 IgG, IgM, and IgA were detected in healthy individuals, we identified serological signatures associated with SARS-CoV-2 antigen-specific Fc{gamma} receptor binding, which accurately distinguished COVID-19 patients from healthy individuals and suggested that SARS-CoV-2 induces qualitative changes to antibody Fc upon infection, enhancing Fc{gamma} receptor engagement. Vastly different serological signatures were observed between healthy children and elderly, with markedly higher cross-reactive SARS-CoV-2 IgA and IgG observed in elderly, whereas children displayed elevated SARS-CoV-2 IgM, including receptor binding domain-specific IgM with higher avidity. These results suggest that less-experienced humoral immunity associated with higher IgM, as observed in children, may have the potential to induce more potent antibodies upon SARS-CoV-2 infection. These key insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1101/2020.05.11.20098459
has license	medrxiv
sha1sum (hex)	e418f3884e7e78ab596ff625fc4de9401b535b66
schema:url	https://doi.org/10.1101/2020.05.11.20098459
resource representing a document's title	Distinct systems serology features in children, elderly and COVID patients
resource representing a document's body	covid:e418f3884e7e78ab596ff625fc4de9401b535b66#body_text
is schema:about of	named entity 'infection' named entity 'coronavirus' named entity 'coronavirus' named entity 'observed' named entity 'cross-reactive' »more»

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