About: MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1

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About: MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1
Creator	Liu, Min Wang, Chunmei Tang, Hua Fan, Hongxia Li, Yixuan »more»
source	PMC
abstract	MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression. It has been reported that miRNAs are involved in host-virus interaction, but evidence that cellular miRNAs promote virus replication has been limited. Here, we found that miR-23a promoted the replication of human herpes simplex virus type 1 (HSV-1) in HeLa cells, as demonstrated by a plaque-formation assay and quantitative real-time PCR. Furthermore, interferon regulatory factor 1 (IRF1), an innate antiviral molecule, is targeted by miR-23a to facilitate viral replication. MiR-23a binds to the 3′UTR of IRF1 and down-regulates its expression. Suppression of IRF1 expression reduced RSAD2 gene expression, augmenting HSV-1 replication. Ectopic expression of IRF1 abrogated the promotion of HSV-1 replication induced by miR-23a. Notably, IRF1 contributes to innate antiviral immunity by binding to IRF-response elements to regulate the expression of interferon-stimulated genes (ISGs) and apoptosis, revealing a complex interaction between miR-23a and HSV-1. MiR-23a thus contributes to HSV-1 replication through the regulation of the IRF1-mediated antiviral signal pathway, which suggests that miR-23a may represent a promising target for antiviral treatments.
has issue date	2014-12-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0114021
bibo:pmid	25461762
has license	cc-by
sha1sum (hex)	e1bceb4ec14b80d88dd6375165847aa049588738
schema:url	https://doi.org/10.1371/journal.pone.0114021
resource representing a document's title	MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1
has PubMed Central identifier	PMC4252059
has PubMed identifier	25461762
schema:publication	PLoS One
resource representing a document's body	covid:e1bceb4ec14b80d88dd6375165847aa049588738#body_text
is schema:about of	named entity 'assay' named entity 'target' named entity 'HeLa cells' named entity 'reduced' named entity 'INTERFERON' »more»

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