About: Intramuscular Immunization with Chemokine-Adjuvanted Inactive Porcine Epidemic Diarrhea Virus Induces Substantial Protection in Pigs

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intramuscular Immunization with Chemokine-Adjuvanted Inactive Porcine Epidemic Diarrhea Virus Induces Substantial Protection in Pigs
Creator	Chang, Hui-Wen Chang, Yen-Chen Kao, Chi-Fei Hsu, Chin-Wei Hsueh, Fu-Chun
source	PMC
abstract	Intramuscular (IM) immunization is generally considered incapable of generating a protective mucosal immune response. In the swine industry, attempts to develop a safe and protective vaccine for controlling porcine epidemic diarrhea (PED) via an IM route of administration have been unsuccessful. In the present study, porcine chemokine ligand proteins CCL25, 27, and 28 were constructed and stably expressed in the mammalian expression system. IM co-administration of inactivated PEDV (iPEDV) particles with different CC chemokines and Freund’s adjuvants resulted in recruiting CCR9+ and/or CCR10+ inflammatory cells to the injection site, thereby inducing superior systemic PEDV specific IgG, fecal IgA, and viral neutralizing antibodies in pigs. Moreover, pigs immunized with iPEDV in combination with CCL25 and CCL28 elicited substantial protection against a virulent PEDV challenge. We show that the porcine CC chemokines could be novel adjuvants for developing IM vaccines for modulating mucosal immune responses against mucosal transmissible pathogens in pigs.
has issue date	2020-02-24(xsd:dateTime)
bibo:doi	10.3390/vaccines8010102
bibo:pmid	32102459
has license	cc-by
sha1sum (hex)	e163fe50949e69946e890d637ce3be209fd61cc5
schema:url	https://doi.org/10.3390/vaccines8010102
resource representing a document's title	Intramuscular Immunization with Chemokine-Adjuvanted Inactive Porcine Epidemic Diarrhea Virus Induces Substantial Protection in Pigs
has PubMed Central identifier	PMC7157555
has PubMed identifier	32102459
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:e163fe50949e69946e890d637ce3be209fd61cc5#body_text
is schema:about of	named entity 'mucosal immune response' named entity 'site' named entity 'viral' named entity 'Chemokine' named entity 'MODULATING' »more»

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