About: Gene families with stochastic exclusive gene choice underlie cell adhesion in mammalian cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Gene families with stochastic exclusive gene choice underlie cell adhesion in mammalian cells
Creator	Becskei, Attila Biozentrum, Faravelli, Simone Iakovlev, Mikhail
source	BioRxiv
abstract	Exclusive stochastic gene choice combines precision with diversity. This regulation enables most T-cells to express exactly one T-cell receptor isoform chosen from a large repertoire, and to react precisely against diverse antigens. Some cells express two receptor isoforms, revealing the stochastic nature of this process. A similar regulation of odorant receptors and protocadherins enable cells to recognize odors and confer individuality to cells in neuronal interaction networks, respectively. We explored whether genes in other families are expressed exclusively by analyzing single cell RNA-seq data with a simple metric. Chromosomal segments and families are more likely to express genes concurrently than exclusively, possibly due to the evolutionary and biophysical aspects of shared regulation. Nonetheless, gene families with exclusive gene choice were detected in multiple cell types, most of them are membrane proteins involved in ion transport and cell adhesion, suggesting the coordination of these two functions. Thus, stochastic exclusive expression extends beyond the prototypical families, permitting precision in gene choice to be combined with the diversity of intercellular interactions.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.08.24.264747
has license	biorxiv
sha1sum (hex)	e0f9a283bfa7cd9647c7ac5164ea5c5e2be411b0
schema:url	https://doi.org/10.1101/2020.08.24.264747
resource representing a document's title	Gene families with stochastic exclusive gene choice underlie cell adhesion in mammalian cells
schema:publication	bioRxiv
resource representing a document's body	covid:e0f9a283bfa7cd9647c7ac5164ea5c5e2be411b0#body_text
is schema:about of	named entity 'isoform' named entity 'gene' named entity 'odors' named entity 'enable' named entity 'membrane proteins' »more»

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