About: Kawasaki disease, autoimmune disorders, and cancer: a register-based study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Kawasaki disease, autoimmune disorders, and cancer: a register-based study
Creator	Andersen, Niels Søgaard, Peter Torp-Pedersen, Christian Munck Nielsen, Troels
source	Medline; PMC
abstract	Kawasaki disease has well-described cardiovascular complications. However, the association to autoimmunity and cancer in the long term is not well described. We investigated theses associations using a registry-based matched cohort follow-up study of patients diagnosed with Kawasaki disease. Patients with Kawasaki disease were included and matched 1:5 to a population control group, matched by birth year, sex and incident month of the Kawasaki disease diagnosis. A total of 820 cases < 21 years of age were identified. Median age at diagnosis was 3 years. Median follow-up time was 12 years. Patients with KD were at higher risk of being diagnosed with ischaemic heart disease at 10 years (HR 39.94 (95% CI 5.00–319.28)) and 30 years (HR 8.33 (95% CI 3.03–22.91)). The 10-, 20- and 30-year risks of developing autoimmune disorders were HR 4.23 (95% CI 3.01–5.94), HR 3.23 (95% CI 2.44–4.29) and 2.83 (95% CI, 2.17–3.68), all p < 0.001. Cancer risk was increased after 30 years (HR 2.42 (95% CI, 1.09–5.34)). All-cause mortality after 35 years was also significantly increased (HR 3.14 (95% CI, 1.03–9.60)). Children with KD have increased long-term risks of ischaemic heart disease also of autoimmune disease and cancer, as well as an increased all-cause mortality. The surprisingly increased risk of autoimmunity must be investigated further.
has issue date	2020-08-09(xsd:dateTime)
bibo:doi	10.1007/s00431-020-03768-4
bibo:pmid	32772155
has license	no-cc
sha1sum (hex)	e056a0eff15aaa293dd8bf5b1efd9ce9a7811afb
schema:url	https://doi.org/10.1007/s00431-020-03768-4
resource representing a document's title	Kawasaki disease, autoimmune disorders, and cancer: a register-based study
has PubMed Central identifier	PMC7415012
has PubMed identifier	32772155
schema:publication	Eur J Pediatr
resource representing a document's body	covid:e056a0eff15aaa293dd8bf5b1efd9ce9a7811afb#body_text
is schema:about of	named entity 'study' named entity 'patients' named entity 'surprisingly' named entity '95% CI' named entity 'Kawasaki' »more»

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