About: A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3

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About: A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3
Creator	Wang, Yan Si, Xiaoning Qin, Ying Zhong, Zhaohua Wang, Tianying »more»
source	Elsevier; Medline; PMC
abstract	The capsid proteins of some RNA viruses can translocate to the nucleus and interfere with cellular phenotypes. In this study we found that the VP1 capsid protein of coxsackievirus B3 (CVB3) was dominantly localized in the nucleus of the cells transfected with VP1-expressing plasmid. The VP1 nuclear localization also occurred in the cells infected with CVB3. Truncation analysis indicated that the VP1 nuclear localization sequence located near the C-terminal. The substitution of His220 with threonine completely abolished its translocation. The VP1 proteins of other CVB types might have the nuclear localization potential because this region was highly conserved. Moreover, the VP1 nuclear localization induced cell cycle deregulation, including a prolonged S phase and shortened G2-M phase. Besides these findings, we also found a domain between Ala72 and Phe106 that caused the VP1 truncates dotted distributed in the cytoplasm. Our results suggest a new pathogenic mechanism of CVB.
has issue date	2012-11-25(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.08.040
bibo:pmid	23010168
has license	no-cc
sha1sum (hex)	e036187bc5ac0bd6d05c5d9dba094f716265566c
schema:url	https://doi.org/10.1016/j.virol.2012.08.040
resource representing a document's title	A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3
has PubMed Central identifier	PMC7111942
has PubMed identifier	23010168
schema:publication	Virology
resource representing a document's body	covid:e036187bc5ac0bd6d05c5d9dba094f716265566c#body_text
is schema:about of	named entity 'substitution' named entity 'highly' named entity 'potential' named entity 'coxsackievirus' named entity 'completely' »more»

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