About: MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2

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About: MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
Creator	Zheng, Bo-Jian Jin, Dong-Yan Yuen, Kwok-Yung Zhou, Jie Qin, Chuan »more»
source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) and multi-organ failure(1,2). The high incidence of renal failure in MERS is a unique clinical feature not often found in other human coronavirus infections(3,4). Whether MERS-CoV infects the kidney and how it triggers renal failure are not understood(5,6). Here, we demonstrated renal infection and apoptotic induction by MERS-CoV in human ex vivo organ culture and a nonhuman primate model. High-throughput analysis revealed that the cellular genes most significantly perturbed by MERS-CoV have previously been implicated in renal diseases. Furthermore, MERS-CoV induced apoptosis through upregulation of Smad7 and fibroblast growth factor 2 (FGF2) expression in both kidney and lung cells. Conversely, knockdown of Smad7 effectively inhibited MERS-CoV replication and protected cells from virus-induced cytopathic effects. We further demonstrated that hyperexpression of Smad7 or FGF2 induced a strong apoptotic response in kidney cells. Common marmosets infected by MERS-CoV developed ARDS and disseminated infection in kidneys and other organs. Smad7 and FGF2 expression were elevated in the lungs and kidneys of the infected animals. Our results provide insights into the pathogenesis of MERS-CoV and host targets for treatment. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nmicrobiol.2016.4) contains supplementary material, which is available to authorized users.
has issue date	2016-02-22(xsd:dateTime)
bibo:doi	10.1038/nmicrobiol.2016.4
bibo:pmid	27572168
has license	no-cc
sha1sum (hex)	dfb1d63cc2a6f5a132939099304b20bfb24c1ae4
schema:url	https://doi.org/10.1038/nmicrobiol.2016.4
resource representing a document's title	MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
has PubMed Central identifier	PMC7097571
has PubMed identifier	27572168
schema:publication	Nat Microbiol
resource representing a document's body	covid:dfb1d63cc2a6f5a132939099304b20bfb24c1ae4#body_text
is schema:about of	named entity 'ZOONOTIC DISEASE' named entity 'NONHUMAN PRIMATE' named entity 'RENAL INFECTION' named entity 'HERE' named entity 'CAUSES' »more»

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