About: Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19

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About: Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19
Creator	Smith, Stephen Boppana, Avinash Chao, Kathy Connor, Ruth Dobesh, David »more»
source	MedRxiv
abstract	Background: Identification of risk factors of severe Covid-19 is critical for improving therapies and understanding SARS-CoV-2 pathogenesis. Methods: We analyzed 184 patients hospitalized for Covid-19 in Livingston, New Jersey for clinical characteristics associated with severe disease. Results: The majority of Covid-19 patients had diabetes mellitus (DM) (62.0%), Pre-DM (23.9%) with elevated FBG, or a BMI > 30 with normal HbA1C (4.3%). SARS-CoV-2 infection was associated with new and persistent hyperglycemia in 29 patients, including several with normal HbA1C levels. Forty-four patients required intubation, which occurred significantly more often in patients with DM as compared to non-diabetics. Conclusions: Severe Covid-19 occurs in the presence of impaired glucose metabolism in patients with SARS-CoV-2 infection. The association of dysregulated glucose metabolism and severe Covid-19 suggests a previously unrecognized manifestation of primary SARS-CoV-2 infection. Exploration of pathways by which SARS-CoV-2 impacts glucose metabolism is critical for understanding disease pathogenesis and developing therapies.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.04.20122507
has license	medrxiv
sha1sum (hex)	df6f1f57d7e78cbd59536ad088e85de8c45a072c
schema:url	https://doi.org/10.1101/2020.06.04.20122507
resource representing a document's title	Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19
resource representing a document's body	covid:df6f1f57d7e78cbd59536ad088e85de8c45a072c#body_text
is schema:about of	named entity 'Covid-19' named entity 'severe' named entity 'glucose metabolism' named entity 'SARS-CoV-2' named entity 'obesity' »more»

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