About: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair

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About: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
Creator	Ji, Hong-Long Fang, Xiaohui Matthay, Michael Chang, Jianjun Gibran, Ali »more»
source	BioRxiv
abstract	COVID-19, SARS, and MERS are featured by fibrinolytic dysfunction. To test the role of the fibrinolytic niche in the regeneration of alveolar epithelium, we compared the self-renewing capacity of alveolar epithelial type 2 (AT2) cells and its differentiation to AT1 cells between wild type (wt) and fibrinolytic niche deficient mice (Plau−/− and Serpine1Tg). A significant reduction in both proliferation and differentiation of deficient AT2 cells was observed in vivo and in 3D organoid cultures. This decrease was mainly restored by uPA derived A6 peptide, a binding fragment to CD44 receptors. The proliferative and differential rate of CD44+ AT2 cells was greater than that of CD44− controls. There was a reduction in transepithelial ion transport in deficient monolayers compared to wt cells. Moreover, we found a marked suppression in total AT2 cells and CD44+ subpopulation in lungs from brain dead patients with acute respiratory distress syndrome (ARDS) and a mouse model infected by influenza viruses. Thus, we demonstrate that the fibrinolytic niche can regulate AT2-mediated homeostasis and regeneration via a novel uPA-A6-CD44+-ENaC cascade.
has issue date	2020-03-25(xsd:dateTime)
bibo:doi	10.1101/2020.03.24.006270
has license	biorxiv
sha1sum (hex)	de1f46387f76cec40f588d61832e3acbf2088707
schema:url	https://doi.org/10.1101/2020.03.24.006270
resource representing a document's title	Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
schema:publication	bioRxiv
resource representing a document's body	covid:de1f46387f76cec40f588d61832e3acbf2088707#body_text
is schema:about of	named entity 'reduction' named entity 'AT2' named entity 'CD44' named entity 'infected' named entity 'peptide' »more»

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