About: Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load

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About: Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load
Creator	Pizzorno, Andrés Terrier, Olivier De Lamballerie, Xavier Mentré, France Malvy, Denis »more»
source	Medline; PMC
abstract	We modeled the viral dynamics of 13 untreated patients infected with SARS‐CoV‐2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6‐87% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1002/psp4.12543
bibo:pmid	32558354
has license	cc-by-nc-nd
sha1sum (hex)	dc81703966fcd2862380a6ab9f9dd82713fe8c5a
schema:url	https://doi.org/10.1002/psp4.12543
resource representing a document's title	Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load
has PubMed Central identifier	PMC7323384
has PubMed identifier	32558354
schema:publication	CPT Pharmacometrics Syst Pharmacol
resource representing a document's body	covid:dc81703966fcd2862380a6ab9f9dd82713fe8c5a#body_text
is schema:about of	covid:arg/dc81703966fcd2862380a6ab9f9dd82713fe8c5a named entity 'word count' named entity 'viral load' named entity 'SARS' named entity 'viral load' »more»

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