About: Characterization of the hypersensitive response‐like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway

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About: Characterization of the hypersensitive response‐like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of the hypersensitive response‐like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway
Creator	Chikwamba, Rachel Catharina, Hester Kim, Bo Lotter-Stark, Therese Palmer, Kenneth »more»
source	Medline; PMC
abstract	Griffithsin (GRFT) is an antiviral lectin, originally derived from a red alga, which is currently being investigated as a topical microbicide to prevent transmission of human immunodeficiency virus (HIV). Targeting GRFT to the apoplast for production in Nicotiana benthamiana resulted in necrotic symptoms associated with a hypersensitive response (HR)‐like cell death, accompanied by H(2)O(2) generation and increased PR1 expression. Mannose‐binding lectins surfactant protein D (SP‐D), cyanovirin‐N (CV‐N) and human mannose‐binding lectin (hMBL) also induce salicylic acid (SA)‐dependent HR‐like cell death in N. benthamiana, and this effect is mediated by the lectin's glycan binding activity. We found that secreted GRFT interacts with an endogenous glycoprotein, α‐xylosidase (XYL1), which is involved in cell wall organization. The necrotic effect could be mitigated by overexpression of Arabidopsis XYL1, and by co‐expression of SA‐degrading enzyme NahG, providing strategies for enhancing expression of oligomannose‐binding lectins in plants.
has issue date	2018-05-02(xsd:dateTime)
bibo:doi	10.1111/pbi.12917
bibo:pmid	29509998
has license	cc-by
sha1sum (hex)	d8f8b6d50f16dfbdf817c36004a0424d44f35e93
schema:url	https://doi.org/10.1111/pbi.12917
resource representing a document's title	Characterization of the hypersensitive response‐like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway
has PubMed Central identifier	PMC6131415
has PubMed identifier	29509998
schema:publication	Plant Biotechnol J
resource representing a document's body	covid:d8f8b6d50f16dfbdf817c36004a0424d44f35e93#body_text
is schema:about of	named entity 'SECRETORY PATHWAY' named entity 'CHARACTERIZATION' named entity 'INDUCED' named entity 'LECTIN' named entity 'PHENOMENON' »more»

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