About: Sex‐Related Differences in COVID‐19 Lethality

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sex‐Related Differences in COVID‐19 Lethality
Creator	Pagliaro, Pasquale Penna, Claudia Mercurio, Valentina Tocchetti, Carlo
source	Medline; PMC
abstract	Many countries have been affected by the world‐wide outbreak of COVID‐19. Among Western countries, Italy has been particularly hit at the beginning of the pandemic, immediately after China. In Italy and elsewhere women seem to be less affected then men by severe/fatal COVID‐19 infection, regardless of their age. Despite the evidence that women and men are affected differently by this infection, very few studies consider different therapeutic approaches for the two sexes. Undoubtedly, understanding the mechanisms at the bases of these differences may help to find appropriate and sex specific therapies. Here, we consider that other mechanisms are involved to explain this difference, in addition to the protection attributable to oestrogens. Several X‐linked genes (such as ACE2) and Y‐linked genes (SRY, SOX9) may explain sex differences. Cardiovascular comorbidities are among the major enhancers of virus lethality. In addition, the number of sex‐independent non‐genetic factors that can change susceptibility and mortality is enormous, and many other factors are likely to be considered, including gender and cultural habits in different countries.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1111/bph.15207
bibo:pmid	32698249
has license	no-cc
sha1sum (hex)	d85bb9b5232627323da1a718db6601bf62c88813
schema:url	https://doi.org/10.1111/bph.15207
resource representing a document's title	Sex‐Related Differences in COVID‐19 Lethality
has PubMed Central identifier	PMC7405496
has PubMed identifier	32698249
schema:publication	Br J Pharmacol
resource representing a document's body	covid:d85bb9b5232627323da1a718db6601bf62c88813#body_text
is schema:about of	named entity 'specific' named entity 'Italy' named entity 'pandemic' named entity 'genes' named entity 'therapeutic' »more»

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