About: Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor

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About: Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor
Creator	Li, Shuang Yang, Haitao Zhao, Qi Chen, Cheng Wang, Fenghua »more»
source	Medline; PMC
abstract	Feline infectious peritonitis virus (FIPV) causes a lethal systemic granulomatous disease in wild and domestic cats around the world. Currently, no effective vaccines or drugs have been developed against it. As a member of the genus Alphacoronavirus, FIPV encodes two polyprotein precursors required for genome replication and transcription. Each polyprotein undergoes extensive proteolytic processing, resulting in functional subunits. This process is mainly mediated by its genome-encoded main protease, which is an attractive target for antiviral drug design. In this study, the main protease of FIPV in complex with a Michael acceptor-type inhibitor was crystallized. The complex crystals diffracted to 2.5 Å resolution and belonged to space group I422, with unit-cell parameters a = 112.3, b = 112.3, c = 102.1 Å. There is one molecule per asymmetric unit.
has issue date	2014-11-14(xsd:dateTime)
bibo:doi	10.1107/s2053230x14022390
bibo:pmid	25484209
has license	green-oa
sha1sum (hex)	d83c529b63855bf62a7a302bfb11d5eb950aa6bc
schema:url	https://doi.org/10.1107/s2053230x14022390
resource representing a document's title	Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor
has PubMed Central identifier	PMC4259223
has PubMed identifier	25484209
schema:publication	Acta Crystallographica Section F Structural Biology Communications
resource representing a document's body	covid:d83c529b63855bf62a7a302bfb11d5eb950aa6bc#body_text
is schema:about of	named entity 'study' named entity 'Each' named entity 'member' named entity 'effective' named entity 'mediated' »more»

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