About: Interferon Response in Hepatitis C Virus (HCV) Infection: Lessons from Cell Culture Systems of HCV Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interferon Response in Hepatitis C Virus (HCV) Infection: Lessons from Cell Culture Systems of HCV Infection
Creator	Shin, Eui-Cheol Kew Yoon, Seung Soo, Pil
source	PMC
abstract	Hepatitis C virus (HCV) is a positive-stranded RNA virus that infects approximately 130–170 million people worldwide. In 2005, the first HCV infection system in cell culture was established using clone JFH-1, which was isolated from a Japanese patient with fulminant HCV infection. JFH-1 replicates efficiently in hepatoma cells and infectious virion particles are released into the culture supernatant. The development of cell culture-derived HCV (HCVcc) systems has allowed us to understand how hosts respond to HCV infection and how HCV evades host responses. Although the mechanisms underlying the different outcomes of HCV infection are not fully understood, innate immune responses seem to have a critical impact on the outcome of HCV infection, as demonstrated by the prognostic value of IFN-λ gene polymorphisms among patients with chronic HCV infection. Herein, we review recent research on interferon response in HCV infection, particularly studies using HCVcc infection systems.
has issue date	2015-10-07(xsd:dateTime)
bibo:doi	10.3390/ijms161023683
bibo:pmid	26457705
has license	cc-by
sha1sum (hex)	d722d17111a045ac6a1427a5ec6967285eea73e0
schema:url	https://doi.org/10.3390/ijms161023683
resource representing a document's title	Interferon Response in Hepatitis C Virus (HCV) Infection: Lessons from Cell Culture Systems of HCV Infection
has PubMed Central identifier	PMC4632721
has PubMed identifier	26457705
schema:publication	Int J Mol Sci
resource representing a document's body	covid:d722d17111a045ac6a1427a5ec6967285eea73e0#body_text
is schema:about of	named entity 'Hepatitis C virus' named entity 'respond' named entity 'HCV' named entity 'Cell' named entity 'RESPONSE' »more»

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