About: Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells

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About: Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
Creator	Castilla, Viviana Scolaro, Luis Cuervo, Eugenia Fernández Bell-Fano, Pablo Linero, Florencia
source	Medline; PMC
abstract	In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, emphasizing the relevance of this pathway in the establishment and maintenance of persistent infection in vitro. During the course of infection, JUNV-infected Vero cells showed a typical cytopathic effect that may be ascribed to apoptotic cell death. Treatment of infected cultures with Ly294002, an inhibitor of the PI3K/Akt pathway, produced an apoptotic response similar to that observed for uninfected cells treated with the drug. This result suggests that virus-induced activation of the PI3K/Akt pathway does not deliver a strong enough anti-apoptotic signal to explain the low proportion of apoptotic cells observed during infection. Also, inhibition of the PI3K/Akt pathway during the acute stage of infection did not prevent the establishment of persistence. Furthermore, treatment of persistently JUNV-infected cells with Ly294002 did not alter viral protein expression. These findings indicate that despite the positive modulation of the PI3/Akt pathway during Junín virus entry, this would not play a critical role in the establishment and maintenance of JUNV persistence in Vero cells.
has issue date	2014-12-07(xsd:dateTime)
bibo:doi	10.1007/s00705-014-2298-6
bibo:pmid	25488290
has license	no-cc
sha1sum (hex)	d6580eec2b617690edcfa198a093c98bffdb33a2
schema:url	https://doi.org/10.1007/s00705-014-2298-6
resource representing a document's title	Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
has PubMed Central identifier	PMC7087115
has PubMed identifier	25488290
schema:publication	Arch Virol
resource representing a document's body	covid:d6580eec2b617690edcfa198a093c98bffdb33a2#body_text
is schema:about of	named entity 'ESTABLISHMENT' named entity 'PI3K/Akt pathway' named entity 'cells' named entity 'kinase' named entity 'cytopathic' »more»

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