About: A prospect on the use of antiviral drugs to control local outbreaks of COVID-19

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About: A prospect on the use of antiviral drugs to control local outbreaks of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A prospect on the use of antiviral drugs to control local outbreaks of COVID-19
Creator	Neyts, Johan Vandamme, Anne-Mieke Hens, Niel Torneri, Andrea Libin, Pieter »more»
source	MedRxiv
abstract	Background: Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation and quarantine, have been shown to decrease and delay the burden of the ongoing epidemic. With respect to the ongoing COVID-19 epidemic, recent modelling work shows that this intervention technique may be inadequate to control local outbreaks, even when perfect isolation is assumed. Furthermore, the effect of infectiousness prior to symptom onset combined with a significant proportion of asymptomatic infectees further complicates the use of contact tracing. Antivirals, which decrease the viral load and reduce the infectiousness, could be integrated in the control measures in order to augment the feasibility of controlling the epidemic. Methods: Using a simulation-based model of viral transmission we tested the efficacy of different intervention measures for the control of COVID-19. For individuals that were identified through contact tracing, we evaluate two procedures: monitoring individuals for symptoms onset and testing of individuals. Moreover, we investigate the effect of a potent antiviral compound on the contact tracing process. Findings: The use of an antiviral drug, in combination with contact tracing, quarantine and isolation, results in a significant decrease of the final size, the peak incidence, and increases the probability that the outbreak will fade out. Interpretation: For an infectious disease in which presymptomatic infections are plausible, an intervention measure based on contact tracing performs better when realized together with testing instead of monitoring, provided that the test is able to detect infections during the incubation period. In addition, in all tested scenarios, the model highlights the benefits of the administration of an antiviral drug in addition to quarantine, isolation and contact tracing. The resulting control measure, could be an effective strategy to control local and re-emerging outbreaks of COVID-19.
has issue date	2020-03-20(xsd:dateTime)
bibo:doi	10.1101/2020.03.19.20038182
has license	medrxiv
sha1sum (hex)	d37e4948cc2342320608f44affdda2cafee28a61
schema:url	https://doi.org/10.1101/2020.03.19.20038182
resource representing a document's title	A prospect on the use of antiviral drugs to control local outbreaks of COVID-19
resource representing a document's body	covid:d37e4948cc2342320608f44affdda2cafee28a61#body_text
is schema:about of	named entity 'viral transmission' named entity 'antiviral drugs' named entity 'TOOL' named entity 'BASED' named entity 'INCIDENCE' »more»

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