About: The CoV-2 outbreak: how hematologists could help to fight Covid-19

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About: The CoV-2 outbreak: how hematologists could help to fight Covid-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The CoV-2 outbreak: how hematologists could help to fight Covid-19
Creator	Lucenteforte, Ersilia Baglietto, Laura Baldini, Chiara Balducci, Serena Baratè, Claudia »more»
source	Elsevier; Medline; PMC
abstract	COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). Hematologists are confident with these situations requiring a prompt therapeutic approach for switching off the uncontrolled cytokine release; here, we discuss pros and cons of drugs that are already employed in hematology in the light of their possible application in COVID-19. The most promising drugs might be: Ruxolitinib, a JAK1/2 inhibitor, with a rapid and powerful anti-cytokine effect, tyrosine kinase inhibitors (TKIs), with their good anti-inflammatory properties, and perhaps the anti-Cd26 antibody Begelomab. We also present immunological data from gene expression experiments where TKIs resulted effective anti-inflammatory and pro-immune drugs. A possible combined treatment algorithm for COVID-19 is here proposed.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.1016/j.phrs.2020.104866
bibo:pmid	32387301
has license	no-cc
sha1sum (hex)	d2d7fd6c3a7cd6d2c8bf9f465d9de4749fedd1ee
schema:url	https://doi.org/10.1016/j.phrs.2020.104866
resource representing a document's title	The CoV-2 outbreak: how hematologists could help to fight Covid-19
has PubMed Central identifier	PMC7202852
has PubMed identifier	32387301
schema:publication	Pharmacol Res
resource representing a document's body	covid:d2d7fd6c3a7cd6d2c8bf9f465d9de4749fedd1ee#body_text
is schema:about of	named entity 'point' named entity 'cytokine' named entity 'antibody' named entity 'COVID-19' named entity 'manifestations' »more»

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