About: The differing pathophysiologies that underlie COVID‐19 associated perniosis and thrombotic retiform purpura: a case series

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The differing pathophysiologies that underlie COVID‐19 associated perniosis and thrombotic retiform purpura: a case series Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The differing pathophysiologies that underlie COVID‐19 associated perniosis and thrombotic retiform purpura: a case series
Creator	Magro, C Magro, Cynthia Mulvey, J Laurence, J Grossman, M »more»
source	Medline; PMC
abstract	BACKGROUND: There are two distinctive acral manifestations of COVID‐19 embodying disparate clinical phenotypes: one is perniosis occurring in mildly symptomatic patients, typically children; the second is the thrombotic retiform purpura of critically ill COVID19 adults. MATERIALS AND METHODS: We compare light‐microscopic, phenotypic, cytokine, and SARS‐CoV‐2 protein and RNA profiles in COVID‐19‐associated perniosis of mildly symptomatic or asymptomatic patients with the thrombotic retiform purpura of critical patients with COVID‐19. RESULTS: The COVID‐19‐associated perniosis exhibited vasocentric and eccrinotropic T‐cell and monocyte‐derived CD11c, CD14, and CD123+ dendritic cell infiltrates. Both COVID associated and idiopathic perniosis showed striking expression of the type I interferon‐inducible myxovirus resistance protein‐A (MXA), an established marker for type I interferon signaling in tissue. SARS‐CoV‐2 RNA, IL‐ 6 and caspase 3 were minimally expressed and confined to mononuclear inflammatory cells. The biopsies from livedo/retiform purpura showed pauci‐inflammatory vascular thrombosis without any MXA decoration. Blood vessels exhibited extensive complement deposition with endothelial cell localization of SARS‐CoV‐2 protein, IL6, and caspase 3; SARS CoV‐2 RNA was not seen. CONCLUSION: The COVID‐19‐associated perniosis represents an exaggerated immune reaction to a virus with significant type‐I interferon signaling important to SARS‐CoV‐2 eradication and has implications in regards to a more generalized highly‐inflammatory response. We hypothesize that in the thrombotic retiform purpura of critically ill patients with COVID‐19, the vascular thrombosis in the skin and other organ systems is associated with a minimal interferon response allowing excessive viral replication with release of viral proteins that localize to extrapulmonary endothelium and trigger extensive complement activation.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1111/bjd.19415
bibo:pmid	32779733
has license	no-cc
sha1sum (hex)	d25dc28c34c369e4f34d7871c3617bc7152f4432
schema:url	https://doi.org/10.1111/bjd.19415
resource representing a document's title	The differing pathophysiologies that underlie COVID‐19 associated perniosis and thrombotic retiform purpura: a case series
has PubMed Central identifier	PMC7405151
has PubMed identifier	32779733
schema:publication	Br J Dermatol
resource representing a document's body	covid:d25dc28c34c369e4f34d7871c3617bc7152f4432#body_text
is schema:about of	named entity 'CD68' named entity 'SARS-CoV-2' named entity 'dermal' named entity 'SOCS3' named entity 'perniosis' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software