About: Protective Immunity to Listeria Monocytogenes Infection Mediated by Recombinant Listeria innocua Harboring the VGC Locus

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About: Protective Immunity to Listeria Monocytogenes Infection Mediated by Recombinant Listeria innocua Harboring the VGC Locus Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protective Immunity to Listeria Monocytogenes Infection Mediated by Recombinant Listeria innocua Harboring the VGC Locus
Creator	Chakraborty, Trinad Darji, Ayub Mohamed, Walid Sethi, Shneh Tchatalbachev, Svetlin
source	PMC
abstract	In this study we propose a novel bacterial vaccine strategy where non-pathogenic bacteria are complemented with traits desirable for the induction of protective immunity. To illustrate the proof of principle of this novel vaccination strategy, we use the model organism of intracellular immunity Listeria. We introduced a, low copy number BAC-plasmid harbouring the virulence gene cluster (vgc) of L. monocytogenes (Lm) into the non-pathogenic L. innocua (L.inn) strain and examined for its ability to induce protective cellular immunity. The resulting strain (L.inn::vgc) was attenuated for virulence in vivo and showed a strongly reduced host detrimental inflammatory response compared to Lm. Like Lm, L.inn::vgc induced the production of Type I Interferon's and protection was mediated by Listeria-specific CD8(+) T cells. Rational vaccine design whereby avirulent strains are equipped with the capabilities to induce protection but lack detrimental inflammatory effects offer great promise towards future studies using non-pathogenic bacteria as vectors for vaccination.
has issue date	2012-04-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0035503
bibo:pmid	22536395
has license	cc-by
sha1sum (hex)	d17d9c2e082583da2dba7cfc61995f5af37e6851
schema:url	https://doi.org/10.1371/journal.pone.0035503
resource representing a document's title	Protective Immunity to Listeria Monocytogenes Infection Mediated by Recombinant Listeria innocua Harboring the VGC Locus
has PubMed Central identifier	PMC3334901
has PubMed identifier	22536395
schema:publication	PLoS One
resource representing a document's body	covid:d17d9c2e082583da2dba7cfc61995f5af37e6851#body_text
is schema:about of	named entity 'MEDIATED' named entity 'desirable' named entity 'attenuated' named entity 'vaccine' named entity 'induce' »more»

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