About: Principles and Practice of SARS-CoV-2 Decontamination of N95 Masks with UV-C

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Principles and Practice of SARS-CoV-2 Decontamination of N95 Masks with UV-C
Creator	Epstein, Alexander Goldman, Olivia Huber, Thomas Sakmar, Thomas Stella, Gianna
source	MedRxiv
abstract	A mainstay of personal protective equipment (PPE) during the COVID-19 pandemic is the N95 filtering facepiece respirator. N95 respirators are commonly used to protect healthcare workers from respiratory pathogens, including the novel coronavirus SARS-CoV-2, and are increasingly employed by other frontline workers and the general public. Under routine circumstances, these masks are disposable, single-use items, but extended use and reuse practices have been broadly enacted to alleviate critical supply shortages during the COVID-19 pandemic. While extended-time single use presents a low risk of pathogen transfer, repeated donning and doffing of potentially contaminated masks presents increased risk of pathogen transfer. Therefore, efficient and safe decontamination methods for N95 masks are needed to reduce the risk of reuse and mitigate local supply shortages. Here we review the available literature concerning use of germicidal ultraviolet-C (UV-C) light to decontaminate N95 masks. We propose a practical method for repeated point-of-use decontamination, using commercially-available UV-C crosslinker boxes from molecular biology laboratories or a simple low-cost, custom-designed and fabricated device to expose each side of the mask to 800-1200 mJ/cm2 of UV-C. We measure the dose that penetrated to the interior of the respirators and model the potential germicidal action on SARS-CoV-2. Our experimental results, in combination with modeled data, suggest that a two-minute UV-C treatment cycle should induce a >3-log-order reduction in viral bioburden on the surface of the respirators, and a 2-log order reduction throughout the interior. The resulting exposure is 100-fold less than the dose expected to damage the masks, facilitating repeated decontamination. As such, UV-C germicidal irradiation (UVGI) is a practical strategy for small-scale point-of-use decontamination of N95s.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1101/2020.06.08.20125062
has license	medrxiv
sha1sum (hex)	d1718f04304a1cf71b3264834b842475634a4396
schema:url	https://doi.org/10.1101/2020.06.08.20125062
resource representing a document's title	Principles and Practice of SARS-CoV-2 Decontamination of N95 Masks with UV-C
resource representing a document's body	covid:d1718f04304a1cf71b3264834b842475634a4396#body_text
is schema:about of	named entity 'disposable' named entity 'workers' named entity 'penetrated' named entity 'respirators' named entity 'viral' »more»

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