About: Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

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About: Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
Creator	Shestopalov, Alexander Potapova, Oxana Sharkova, Tatyana Shkurupiy, Vyacheslav
source	PMC
abstract	Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.
has issue date	2013-12-23(xsd:dateTime)
bibo:doi	10.1155/2013/342686
bibo:pmid	24454472
has license	cc-by
sha1sum (hex)	d12f82f17862869b5118dc55c63929adc6597dd4
schema:url	https://doi.org/10.1155/2013/342686
resource representing a document's title	Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
has PubMed Central identifier	PMC3886489
has PubMed identifier	24454472
schema:publication	Clin Dev Immunol
resource representing a document's body	covid:d12f82f17862869b5118dc55c63929adc6597dd4#body_text
is schema:about of	named entity 'PROCESSES' named entity 'LIVER FAILURE' named entity 'INHIBITION' named entity 'ANTIVIRAL RESPONSE' named entity 'HPAI H5N1 VIRUS' »more»

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