About: Inhibition of Rhinovirus Replication In Vitro and In Vivo by Acid-Buffered Saline

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Inhibition of Rhinovirus Replication In Vitro and In Vivo by Acid-Buffered Saline Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of Rhinovirus Replication In Vitro and In Vivo by Acid-Buffered Saline
Creator	Gern, James Swenson, Cheri England, R Mizoguchi, Haruko Mosser, Anne »more»
source	PMC
abstract	Human rhinoviruses (HRVs) are quite sensitive to low pH. To determine whether this characteristic might be a therapeutic target, we evaluated the sensitivity of HRV to low-pH buffers in vitro and in vivo. Our findings confirm that low pH inhibited replication of most HRVs and reduced the replication of influenza virus. Preliminary experiments verified that the surface pH of the human nasopharynx could be transiently lowered to pH ∼4.0 by topical administration of citrate/phosphate (CP) buffers, which was well tolerated. In a pilot experimental colds study, intranasal administration of CP buffer, compared with normal saline, reduced viral shedding by 1 log unit (10(3) vs. 10(4) 50%tissue culture infective dose/mL; P < .01), although respiratory symptoms were not significantly reduced. These findings demonstrate that low-pH buffers have antiviral activity in vivo and suggest that a larger clinical trial is warranted to determine whether this approach could reduce rates of viral transmission.
has issue date	2007-04-15(xsd:dateTime)
bibo:doi	10.1086/512858
bibo:pmid	17357049
has license	no-cc
sha1sum (hex)	d0e0eec3071f8874c438e1466c44b76639d8382b
schema:url	https://doi.org/10.1086/512858
resource representing a document's title	Inhibition of Rhinovirus Replication In Vitro and In Vivo by Acid-Buffered Saline
has PubMed Central identifier	PMC7110134
has PubMed identifier	17357049
schema:publication	J Infect Dis
resource representing a document's body	covid:d0e0eec3071f8874c438e1466c44b76639d8382b#body_text
is schema:about of	named entity 'RHINOVIRUS' named entity 'buffers' named entity 'infective' named entity 'sensitivity' named entity 'human' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software