About: The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus

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About: The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus
Creator	Chen, Shih-Shiung Jong, Ting-Ting Liao, Jiunn-Wang Chang, Shih-Chieh Chien, Maw-Sheng »more»
source	Elsevier; Medline; PMC
abstract	Abstract Aim of the study Isatis indigotica (I. indigotica), Cruciferae, has been used in Chinese medicine for anti-leukemia and anti-severe acute respiratory syndrome (SARS). The aim of this study was to evaluate the cytotoxicity of Isatis indigotica extracts on human leukemia cell line (HL-60) and the antiviral activity on swine pseudorabies virus (PrV) in in vitro assays. Materials and methods Extracts and derived fractions of Isatis indigotica were prepared from root (R) and leaf (L) using methanol (M), ethyl acetate (E) and distilled water (D). The cytotoxic effect of extracts on swine peripheral blood mononuclear cells (PBMCs) and HL-60 was assessed by MTT method. The cytopathic effect (CPE) reduction, plaque reduction and inhibition assays on viral replication, and virucidal activity were further conducted to investigate the anti-PrV activity. Results Indirubin, one of the biological active compounds of Isatis indigotica, had the most significant cytotoxicity on HL-60 cells and inhibitory effect on PrV replication. Extracts from roots and leaves of Isatis indigotica also presented CPE inhibition either before or after infection of PrV on porcine kidney (PK-15) cells. Leaf extracts had better virucidal activity than roots, and ethyl acetate extracts exhibited the highest efficacy among extracts tested. Conclusion Isatis indigotica posses a valuable virucidal effect in disease control of pseudorabies virus infection in swine.
has issue date	2009-05-04(xsd:dateTime)
bibo:doi	10.1016/j.jep.2009.02.028
bibo:pmid	19429341
has license	els-covid
sha1sum (hex)	d04931d795b87d97de6fbf013206543af8961ace
schema:url	https://doi.org/10.1016/j.jep.2009.02.028
resource representing a document's title	The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus
has PubMed Central identifier	PMC7126793
has PubMed identifier	19429341
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:d04931d795b87d97de6fbf013206543af8961ace#body_text
is schema:about of	named entity 'virucidal' named entity 'ethyl acetate' named entity 'Chinese' named entity 'presented' named entity 'control' »more»

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