About: Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome

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About: Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome
Creator	Diehl, Jean-Luc Bouadma, Lila Thiébaut, Rodolphe Hejblum, Boris Wicky, Paul-Henri »more»
source	MedRxiv
abstract	We report a longitudinal analysis of the immune response associated with a fatal case of COVID-19. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2-3 fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in {gamma}{delta} T-cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a proinflammatory cytokine storm, Th1 and Th2 activation, and markers of T-cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.20087239
has license	medrxiv
sha1sum (hex)	cf267e85c23bd3786514713fc5ad29a03039d985
schema:url	https://doi.org/10.1101/2020.05.01.20087239
resource representing a document's title	Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome
resource representing a document's body	covid:cf267e85c23bd3786514713fc5ad29a03039d985#body_text
is schema:about of	named entity 'cytotoxicity' named entity 'Th1' named entity 'ANTIVIRAL' named entity 'IMMUNE RESPONSE' named entity 'OBSERVED' »more»

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