About: Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily
Creator	Amin Jalili, · Askarian, Saeedeh Oskuee, Reza Zohrab, Fatemeh
source	PMC
abstract	The Brevinin peptides are antimicrobial agents obtained from frog skin secretions. Brevinin-2R has attracted many attentions due to its very low hemolytic activity, cationic property, and high affinity to cancer cells. Moreover, it has shown little toxicity against normal mammalian cells, while having killed several tumor cell lines by activation of lysosome-mitochondrial death pathway. In this review, we introduced the Brevinin superfamily with a focus on its therapeutic applications. Next, some unique properties of Brevinins were briefly discussed, including their ability to stimulate insulin secretion, dendritic cell maturation, and wound healing. In this context, we also provide information about the decoration of nanoparticles, such as cerium nano-oxide, by Brevinins. Finally, we addressed their potential for anti-tumor and drug design applications.
has issue date	2018-06-05(xsd:dateTime)
bibo:doi	10.1007/s10989-018-9723-8
bibo:pmid	32214928
has license	no-cc
sha1sum (hex)	c9af9632a0ba1697e4a14525f3059595c2757b0a
schema:url	https://doi.org/10.1007/s10989-018-9723-8
resource representing a document's title	Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily
has PubMed Central identifier	PMC7087712
has PubMed identifier	32214928
schema:publication	Int J Pept Res Ther
resource representing a document's body	covid:c9af9632a0ba1697e4a14525f3059595c2757b0a#body_text
is schema:about of	named entity 'affinity' named entity 'normal' named entity 'cerium' named entity 'Current' named entity 'Applications' »more»

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