About: Faecal immunochemical testing (FIT): Sources of analytical variation based on three years of routine testing in the context of DG30

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About: Faecal immunochemical testing (FIT): Sources of analytical variation based on three years of routine testing in the context of DG30 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Faecal immunochemical testing (FIT): Sources of analytical variation based on three years of routine testing in the context of DG30
Creator	East, James Facilitator, G James, Tim Justice, Steve Macmillan, & »more»
source	MedRxiv
abstract	Aims: To determine analytical capabilities of a commonly used faecal immunochemical test (FIT) to detect haemoglobin (Hb) in the context of NICE guidance DG30, and the likely use of FIT to reprioritise patients delayed by the COVID-19 pandemic. Methods: Data obtained from independent verification studies and clinical testing of the HM-JACKarc FIT method in routine primary care practice were analysed to derive analytical performance characteristics. Results: Detection capabilities for the FIT method were 0.5 microg/g (limit of blank), 1.1 microg/g (limit of detection) and 15.0 microg/g (limit of quantification). 31 of 33 (94%) non-homogenised specimens analysed in triplicate were consistently categorised relative to 10 microg/g compared to all 33 (100%) homogenised specimens. Imprecision in non-homogenised specimens was higher (median 27.8%, (range 20.5% - 48.6%)) than in homogenised specimens (10.2%, (7.0 to 13.5%)). Considerable variation was observed in sequential clinical specimens from individual patients but no positive or negative trend in specimen degradation was observed (p=0.26). Conclusions: The FIT method is capable of detecting Hb at concentrations well below the DG30 threshold of 10 microg/g. However, total imprecision is considerable when including sampling variation. Binary categorisation against a single defined threshold above and below 10 microg/g was more consistent and improved following specimen homogenisation. This approach may be more appropriate when reporting results for symptomatic patients tested in primary care, including those who have had definitive investigation delayed by the COVID-19 pandemic and need to be re-prioritised.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1101/2020.04.15.20066191
has license	medrxiv
sha1sum (hex)	c8900df1a3de667c36c9a27b1d5375bb188e0e4b
schema:url	https://doi.org/10.1101/2020.04.15.20066191
resource representing a document's title	Faecal immunochemical testing (FIT): Sources of analytical variation based on three years of routine testing in the context of DG30
resource representing a document's body	covid:c8900df1a3de667c36c9a27b1d5375bb188e0e4b#body_text
is schema:about of	named entity 'testing' named entity 'patients' named entity 'LOQ' named entity 'LOQ' named entity 'preprint' »more»

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