About: A previously uncharacterized gene in SARS-CoV-2 and the origins of the COVID-19 pandemic

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A previously uncharacterized gene in SARS-CoV-2 and the origins of the COVID-19 pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A previously uncharacterized gene in SARS-CoV-2 and the origins of the COVID-19 pandemic
Creator	Kolokotronis, Sergios-Orestis Meng, Chen Nelson, Chase Goldberg, Tony Ardern, Zachary »more»
source	BioRxiv
abstract	Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with the origins of pandemics, but are still widely overlooked. We identify ORF3c, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not more closely related pangolin-CoVs (Guangdong) or bat-CoVs (RaTG13 and RmYN02). We then document evidence of translation from ribosome profiling and conduct an evolutionary analysis at three levels: between-species (n=21 betacoronavirus genomes), between-host (n=3,978 SARS-CoV-2 consensus sequences), and within-host (401 deeply sequenced SARS-CoV-2 samples). ORF3c has been independently identified and shown to elicit a strong antibody response in COVID-19 patients. However, it has been misclassified as ORF3b, an unrelated gene in other SARS-related betacoronaviruses, leading to confusion and unfounded functional inferences. Our results liken ORF3c to other viral accessory genes and stress the importance of studying OLGs.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1101/2020.05.21.109280
has license	biorxiv
sha1sum (hex)	c6001f71e2a14800bd7b9f864d76a646ace939f4
schema:url	https://doi.org/10.1101/2020.05.21.109280
resource representing a document's title	A previously uncharacterized gene in SARS-CoV-2 and the origins of the COVID-19 pandemic
schema:publication	bioRxiv
resource representing a document's body	covid:c6001f71e2a14800bd7b9f864d76a646ace939f4#body_text
is schema:about of	named entity 'viruses' named entity 'pandemic' named entity 'origins' named entity 'identify' named entity 'genomes' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software